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Friday, September 17, 2021

Do the Experimental mRNA Photographs Have Unexpected Results?

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“Let’s begin with a thought experiment: If an engineering design flaw exists and nobody measures it, can it actually injure individuals or kill them?” a Twitter consumer named Ehden writes.1 He goes on to debate an ignored facet of the COVID mRNA pictures, one thing known as “codon optimization,” which nearly ensures surprising outcomes. Ehden explains:2

“Making an attempt to inform your physique to generate proteins is tough for a lot of causes. One in every of them is the truth that once you attempt to run the protein info through ribosomes which course of that code and generate the protein, it may be very gradual or can get caught throughout the course of.

Fortunately, scientists discovered a method to overcome this drawback, by doing code substitution: as an alternative of utilizing the unique genetic code to generate the protein, they modified the letters within the code so the code can be optimized. This is named Codon Optimization.”

COVID Photographs Use Codon Optimization

A codon consists of three nucleotides, and nucleotides are the constructing blocks of DNA. An August 2021 article in Nature Opinions Drug Discovery, addressed using codon optimization as follows:3

“The open studying body of the mRNA vaccine is probably the most essential part as a result of it accommodates the coding sequence that’s translated into protein.

Though the open studying body is just not as malleable because the non-coding areas, it may be optimized to extend translation with out altering the protein sequence by changing hardly ever used codons with extra incessantly occurring codons that encode the identical amino acid residue.

As an example, the biopharmaceutical firm CureVac AG found that human mRNA codons hardly ever have A or U on the third place and patented a technique that replaces A or U on the third place within the open studying body with G or C. CureVac used this optimization technique for its SARS-CoV-2 candidate CVnCoV …

Though alternative of uncommon codons is a sexy optimization technique, it should be used judiciously. It is because, within the case of some proteins, the slower translation fee of uncommon codons is critical for correct protein folding.

To maximise translation, the mRNA sequence sometimes incorporates modified nucleosides, corresponding to pseudouridine, N1-methylpseudouridine or different nucleoside analogues. As a result of all native mRNAs embody modified nucleosides, the immune system has developed to acknowledge unmodified single-stranded RNA, which is a trademark of viral an infection.

Particularly, unmodified mRNA is acknowledged by sample recognition receptors, corresponding to Toll-like receptor 3 (TLR3), TLR7 and TLR8, and the retinoic acid-inducible gene I (RIGI) receptor. TLR7 and TLR8 receptors bind to guanosine- or uridine-rich areas in mRNA and set off the manufacturing of sort I interferons, corresponding to IFNα, that may block mRNA translation.

The usage of modified nucleosides, significantly modified uridine, prevents recognition by sample recognition receptors, enabling adequate ranges of translation to supply prophylactic quantities of protein.

Each the Moderna and Pfizer–BioNTech SARS-CoV-2 vaccines … comprise nucleoside-modified mRNAs. One other technique to keep away from detection by sample recognition receptors, pioneered by CureVac, makes use of sequence engineering and codon optimization to deplete uridines by boosting the GC content material of the vaccine mRNA.”

A lot of this info was beforehand reviewed in my interview with Stephanie Seneff, Ph.D., and Judy Mikovits, Ph.D. You’ll be able to’t see the article however the video is embedded above. This research was revealed nicely after our interview and merely confirms what Seneff and Mikovits have unraveled of their analysis.

In line with Ehden, 60.9% of the codons in COVID pictures have been optimized, equal to 22.5% of the nucleotides, however he doesn’t specify which shot he’s speaking about, or precisely the place the info got here from.

That each one mRNA COVID pictures are utilizing codon optimization to 1 diploma or one other is obvious, nevertheless. A July 2021 article4 within the journal Vaccines particularly evaluates and feedback on the Pfizer/BioNTech and Moderna mRNA pictures, noting:

“The design of Pfizer/BioNTech and Moderna mRNA vaccines includes many several types of optimizations … The mRNA elements of the vaccine have to have a 5′-UTR to load ribosomes effectively onto the mRNA for translation initiation, optimized codon utilization for environment friendly translation elongation, and optimum cease codon for environment friendly translation termination.

Each 5′-UTR and the downstream 3′-UTR needs to be optimized for mRNA stability. The alternative of uridine by N1-methylpseudourinine (Ψ) complicates a few of these optimization processes as a result of Ψ is extra versatile in wobbling than U. Totally different optimizations can battle with one another, and compromises would have to be made.

I spotlight the similarities and variations between Pfizer/BioNTech and Moderna mRNA vaccines and focus on the benefit and drawback of every to facilitate future vaccine enchancment. Particularly, I level out just a few optimizations within the design of the 2 mRNA vaccines that haven’t been carried out correctly.”

What Can Go Mistaken?

One key take-home from the Nature Opinions Drug Discovery article5 cited above is that changing uncommon codons “should be used judiciously,” as rarer codons can have slower translation charges and a slowed-down fee is definitely obligatory to forestall protein misfolding.

A (adenine) and U (uracil) within the third place are uncommon, and the COVID pictures exchange these A’s and U’s with G’s (guanine) or C’s (cytosine). In line with Seneff, this change leads to a 1,000-fold higher quantity of spike protein in comparison with being contaminated with the precise virus.

What might go incorrect? Effectively, absolutely anything. Once more, the shot induces spike protein at ranges extraordinary in nature (even when SARS-CoV-2 is a “souped up” artifical concoction), and the spike protein is the poisonous a part of the virus accountable for probably the most distinctive results of the virus, such because the blood clotting issues, neurological issues and coronary heart harm.

So, to count on the COVID shot to not produce these sorts of results can be somewhat naïve. The codon switches may also end in protein misfolding, which is equally unhealthy information. As defined by Seneff in our earlier interview:

“The spike proteins that these mRNA vaccines are producing … aren’t ready to enter the membrane, which I feel goes to encourage it to turn into a problematic prion protein. Then, when you will have irritation, it upregulates alpha-synuclein [a neuronal protein that regulates synaptic traffic and neurotransmitter release].

So, you are going to get alpha-synuclein drawn into misfolded spike proteins, turning into a multitude contained in the dendritic cells within the germinal facilities within the spleen. And they will bundle up all this crud into exosomes and launch them. They’re then going to journey alongside the vagus nerve to the brainstem and trigger issues like Parkinson’s illness.

So, I feel this can be a full setup for Parkinson’s illness … It’ll push ahead the date at which somebody who has a propensity in the direction of Parkinson’s goes to get it.

And it is in all probability going to trigger individuals to get Parkinson’s who by no means would have gotten it within the first place — particularly in the event that they preserve getting the vaccine yearly. Yearly you do a booster, you deliver the date that you will get Parkinson’s ever nearer.”

Immune Dysfunction and Viral Flare-Ups

Different important threats embody immune dysfunction and the flare-up of latent viral infections, which is one thing Mikovits has been warning about. In our earlier interview, she famous:

“We use poly(I:C) [a toll-like receptor 3 agonist] to sign the cell to activate the sort I interferon pathway, and since [the spike protein your body produces in response to the COVID shot] is an unnatural artificial envelope, you are not seeing poly(I:C), and you are not [activating] the Kind I interferon pathway.

You’ve got bypassed the plasmacytoid dendritic cell, which mixed with IL-10, by speaking to the regulatory B cells, decides what subclasses of antibodies to place out. So, you have bypassed the communication between the innate and adaptive immune response. You now miss the signaling of the endocannabinoid receptors …

A big a part of Dr. [Francis] Ruscetti’s and my work during the last 30 years has been to indicate you do not want an infectious transmissible virus — simply items and components of those viruses are worse, as a result of in addition they activate hazard indicators. They act like hazard indicators and pathogen-associated molecular patterns.

So, it synergistically leaves that inflammatory cytokine signature on that spins your innate immune response uncontrolled. It simply can’t sustain with the myelopoiesis [the production of cells in your bone marrow]. Therefore you see a skew-away from the mesenchymal stem cell in the direction of TGF-beta regulated hematopoietic stem cells.

This implies you could possibly see bleeding issues on each ends. You’ll be able to’t make sufficient firetrucks to ship to the hearth. Your innate immune response cannot get there, and then you definitely’ve simply bought a complete practice wreck of your immune system.”

We’re now seeing studies of herpes and shingles an infection following COVID-19 injection, and that is exactly what you may count on in case your Kind I interferon pathway is disabled. That’s not the top of your potential troubles, nevertheless, as these coinfections might speed up different illnesses as nicely.

For instance, herpes viruses have been implicated as a set off of each AIDS6 and myalgic encephalomyelitis7 (persistent fatigue syndrome or ME-CFS). In line with Mikovits, these illnesses don’t seem till viruses from completely different households accomplice up and retroviruses take out the Kind 1 interferon pathway. Long run, the COVID mass injection marketing campaign could also be laying the muse for a quickly approaching avalanche of a variety of debilitating persistent diseases.

Are COVID Photographs Appropriately Optimized?

As famous within the Vaccines article cited earlier, the codon optimization within the Pfizer and Moderna pictures may very well be problematic:8

“As mammalian host cells assault unmodified exogeneous RNA, all U nucleotides have been changed by N1-methylpseudouridine (Ψ). Nevertheless, Ψ wobbles extra in base-pairing than U and might pair not solely with A and G, but additionally, to a lesser extent, with C and U.

That is prone to improve misreading of a codon by a near-cognate tRNA. When nucleotide U in cease codons was changed by Ψ, the speed of misreading of a cease codon by a near-cognate tRNAs elevated.

Such readthrough occasions wouldn’t solely lower the variety of immunogenic proteins, but additionally produce an extended protein of unknown destiny with probably deleterious results …

The designers of each vaccines thought of CGG because the optimum codon within the CGN codon household and recoded virtually all CGN codons to CGG … [M]ultiple traces of proof counsel that CGC is a greater codon than CGG. The designers of the mRNA vaccines (particularly mRNA-1273) selected a incorrect codon because the optimum codon.”

The paper additionally factors out the significance of vaccine mRNA to be translated precisely and never merely successfully, as a result of if the incorrect amino acids are included, it might confuse your immune system and stop it from figuring out the proper targets.

Accuracy can also be vital in translation termination, and right here it comes all the way down to deciding on the proper cease codons. Cease codons (UAA, UAG or UGA), when current on the finish of an mRNA coding sequence indicators the termination of protein synthesis.

In line with the writer, each Pfizer and Moderna chosen lower than optimum cease codons. “UGA is a poor selection of a cease codon, and UGAU in Pfizer/BioNTech and Moderna mRNA vaccines may very well be even worse,” she says.

What Well being Issues Can We Count on to See Extra Of?

Whereas the number of illnesses we may even see an increase in because of this vaccination marketing campaign are myriad, some common predictions could be made. We’ve already seen a large uptick in blood clotting issues, coronary heart assaults and stroke, in addition to coronary heart irritation.

Extra long run, Seneff believes we’ll see a major rise in most cancers, accelerated Parkinson’s-like illnesses, Huntington’s illness, and all sorts of autoimmune illnesses and neurodegenerative issues.

Mikovits additionally suspects many will develop persistent and debilitating illnesses and can die prematurely. At highest danger, she locations those that are asymptomatically contaminated with XMRVs and gammaretroviruses from contaminated typical vaccines. The COVID shot will successfully speed up their dying by crippling their immune perform. “The youngsters which are extremely vaccinated, they’re ticking time bombs,” Mikovits mentioned in my Might 2021 interview. 

What Are the Choices?

Whereas all of that is extremely problematic, there may be hope. From my perspective, I consider the perfect factor you are able to do is to construct your innate immune system. To try this, it’s worthwhile to turn into metabolically versatile and optimize your weight loss plan. You’ll additionally wish to be sure that your vitamin D degree is optimized to between 60 ng/mL and 80 ng/mL (100 nmol/L to 150 nmol/L).

I additionally suggest time-restricted consuming, the place you eat all of your meals for the day inside a six- to eight-hour window. Time-restricted consuming may also upregulate autophagy, which can assist digest and take away spike protein. Keep away from all vegetable oils and processed meals. Concentrate on certified-organic meals to attenuate your glyphosate publicity.

Sauna remedy may additionally be useful. It upregulates warmth shock proteins, which might help refold misfolded proteins. Additionally they tag broken proteins and goal them for removing.

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